PT‑141 (Bremelanotide) – 10mg

PT‑141 (Bremelanotide) is a synthetic cyclic heptapeptide and analogue of α‑melanocyte‑stimulating hormone (α‑MSH). It is widely used in laboratory research exploring melanocortin receptor activity, neuroendocrine signalling, and central nervous system pathways.

Unlike compounds that act on peripheral vascular mechanisms, PT‑141 is primarily studied for its central melanocortin receptor interactions, particularly MC3R and MC4R, making it a valuable tool for research into neural signalling, receptor affinity, and behavioural neurobiology.

This peptide is supplied as a high‑purity lyophilised powder for controlled research use only.

Areas of Research Interest
Melanocortin Receptor Activation
Used in studies examining MC3R and MC4R signalling pathways and their downstream neural responses.

Central Neurobiology Models
Investigated in preclinical environments exploring CNS‑mediated behavioural pathways and neuroendocrine signalling.

Receptor Affinity & Peptide Structure Studies
Included in research analysing cyclic peptide stability, receptor binding characteristics, and structure–activity relationships.

Inflammatory & Stress Pathways
Explored in models studying melanocortin‑related modulation of inflammatory and stress‑response mechanisms.

These research areas highlight PT‑141 as a key reagent for laboratories investigating melanocortin biology and CNS‑related peptide activity.

Technical Information
Chemical Name: Bremelanotide (PT‑141)

Synonyms: PT141, Cyclo‑[Nle4, Asp5, D‑Phe7, Lys10]‑α‑MSH

Molecular Formula: C₅₀H₆₈N₁₄O₁₀

Molecular Weight: 1025.2 g/mol

Sequence: Ac‑Nle‑Asp‑His‑D‑Phe‑Arg‑Trp‑Lys‑OH (cyclic lactam)

CAS Number: 189691‑06‑3

Classification: Melanocortin receptor agonist / α‑MSH analogue

Storage Guidelines
Lyophilised peptide is stable at room temperature for short periods.

For long‑term storage, keep at –20°C or below.

After reconstitution, store at 2–8°C.

Stability depends on solvent and laboratory handling conditions.

Solubility
Soluble in sterile water, saline, or bacteriostatic water.

References (Research Context Only)
Pfaus et al. – Melanocortin receptor activation in CNS models

Molinoff et al. – Characterisation of PT‑141 as a melanocortin agonist

Diamond et al. – Preclinical studies on receptor‑mediated signalling

(Full citations available upon request. Direct links removed for compliance.)

Compliance Notice
For laboratory research use only. Not for human or animal administration.